{"id":3179,"date":"2023-09-25T14:47:13","date_gmt":"2023-09-25T12:47:13","guid":{"rendered":"https:\/\/www.avn-france.com\/installation-salle-blanche-secteur-pharmaceutique\/"},"modified":"2026-09-17T15:56:16","modified_gmt":"2026-09-17T13:56:16","slug":"cleanroom-installation-pharmaceutical-industry","status":"publish","type":"page","link":"https:\/\/www.avn-france.com\/en\/cleanroom-installation-pharmaceutical-industry\/","title":{"rendered":"Pharmaceutique &#8211; EN"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; el_class=&#8221;txt-blanc&#8221; css=&#8221;.vc_custom_1765293247823{background-color: #384955 !important;}&#8221;][vc_column][vc_column_text el_class=&#8221;grand-titre tres-fort&#8221;]<\/p>\n<h1>RABS: Restricted Access Barrier System or Isolator<\/h1>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1708597892709{background-color: #384955 !important;}&#8221; el_class=&#8221;txt-blanc&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<p style=\"text-align: justify;\">We support you in the study and design of <strong class=\"d2b1\">RABS barrier technologies<\/strong> for the compliance upgrade of your production tools.<br \/>\nAnnex 1 of the Good Manufacturing Practices (EU GMP) sets out the rules for the manufacture of sterile medicinal products. After several years of consultation and revisions, a new version was officially published in August 2022. It imposes stricter requirements to minimise the risks of microbial, particulate and pyrogen contamination using <strong class=\"d2b1\">RABS<\/strong> or isolators. This update will naturally trigger many changes for sterile medicine manufacturers. AVN puts all its experience at your disposal to enable a fast and effective compliance upgrade of your production tools. AVN combines every mechanical and automation skill within its engineering department and carries out manufacturing and assembly in-house. This end-to-end control of the design and production chain is why AVN can respond with confidence to your various needs.<\/p>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;3224&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; css_animation=&#8221;fadeInRight&#8221; el_class=&#8221;border-img-pharma&#8221;][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1768556599164{background-color: #384955 !important;}&#8221; el_class=&#8221;range-gris-fonce-bas arrondie-blanc&#8221;][vc_column][vc_empty_space height=&#8221;200px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text el_class=&#8221;moyen-titre tres-fort&#8221;]<\/p>\n<h3>RABS \u2014 Technical details of pharmaceutical isolators<\/h3>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<p style=\"text-align: justify;\">The <strong class=\"d2b1\">term Barrier Technologies<\/strong> is a generic label that covers <strong class=\"d2b1\">RABS<\/strong> and <strong>Isolators<\/strong>. Thanks to their design and their tightness, isolators create a controlled aseptic containment space in which critical operations can take place with maximum safety. Contamination risk control is further enhanced through the integration of a decontamination system. <strong class=\"d2b1\">RABS<\/strong> are classified into open or closed systems and into passive or active systems. The diagram below graphically highlights the specific features of each system:<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t\t<!-- START rabs sch\u00e9ma EN REVOLUTION SLIDER 6.6.16 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_102_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_102_1\" style=\"\" data-version=\"6.6.16\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-147\" data-title=\"Slide\" data-in=\"o:0;\" data-out=\"a:false;\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"\/\/www.avn-france.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"Slide\" title=\"Pharmaceutique &#8211; EN\" class=\"rev-slidebg tp-rs-img rs-lazyload\" 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\n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:r;y:90px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:310px;h:373px;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:7;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.avn-france.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"310\" height=\"373\" data-lazyload=\"\/\/www.avn-france.com\/wp-content\/uploads\/2025\/12\/RABS-FERME-ACTIF.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-3\" \n\t\t\t\t\t\t\t\tdata-type=\"image\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;y:90px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:310px;h:379px;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:8;\"\n\t\t\t\t\t\t\t><img decoding=\"async\" src=\"\/\/www.avn-france.com\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" alt=\"\" class=\"tp-rs-img rs-lazyload\" width=\"310\" height=\"379\" data-lazyload=\"\/\/www.avn-france.com\/wp-content\/uploads\/2025\/12\/RABS-OUVERT-ACTIF-1.png\" data-no-retina> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-4\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#384955\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:65px;y:30px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;fw:500;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:11;font-family:'Roboto';\"\n\t\t\t\t\t\t\t>RABS PASSIF OPEN \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-5\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#384955\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:c;y:30px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;fw:500;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:10;font-family:'Roboto';\"\n\t\t\t\t\t\t\t>RABS ACTIVE OPEN \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-6\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#384955\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:r;xo:65px;y:33px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;fw:500;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:9;font-family:'Roboto';\"\n\t\t\t\t\t\t\t>RABS CLOSED RABS \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-7\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#0c0c0c\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:586px;y:273px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:13;fw:700;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:16;font-family:'Roboto';\"\n\t\t\t\t\t\t\t>(ISO 4.8) \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-102-slide-147-layer-8\" 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SLIDER -->\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: left;\">To guarantee an ISO 4.8\/5 laminar environment, a <strong>RABS<\/strong> comprises several equipment items or functionalities:<\/p>\n<ul>\n<li>Unidirectional airflow (laminar flow)<\/li>\n<li>Rigid barriers<\/li>\n<li>Gloves and glove integrity testing<\/li>\n<li>Sterile material transfer<\/li>\n<\/ul>\n<p style=\"text-align: left;\">Our specialist teams take all your challenges into account to propose customised, turnkey solutions tailored to each of these issues. After approval of the 3D design, AVN can validate the ergonomics on a full-scale mock-up (in our workshop or on site).<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column css_animation=&#8221;fadeInUp&#8221;][vc_single_image image=&#8221;3225&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1768556617694{background-color: #384955 !important;}&#8221; el_class=&#8221;range-gris-fonce-haut arrondie-blanc&#8221;][vc_column][vc_empty_space height=&#8221;200px&#8221;][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1765293262382{background-color: #384955 !important;}&#8221;][vc_column el_class=&#8221;txt-blanc&#8221;][vc_column_text el_class=&#8221;moyen-titre tres-fort txt-fort&#8221;]<\/p>\n<h3>Advanced functionalities for a smart and compliant RABS<\/h3>\n<p>[\/vc_column_text][vc_column_text el_class=&#8221;txt-blanc&#8221;]Beyond the physical barrier, a modern <strong class=\"d2b\">RABS<\/strong> integrates digital and safety functionalities to meet the growing requirements of pharmaceutical and regulated environments. At AVN, we deliver systems that are ergonomic, connected and auditable at once.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text el_class=&#8221;moyen-titre tres-fort txt-fort txt-blanc&#8221;]<\/p>\n<h3>Control via HMI or Panel PC: ergonomics and centralised control<\/h3>\n<p>[\/vc_column_text][vc_column_text el_class=&#8221;txt-blanc&#8221;]Our <strong class=\"d2b\">RABS<\/strong> can be controlled through a <strong class=\"d2b1\">touch-screen Human-Machine Interface<\/strong> (HMI) or an industrial Panel PC integrated into the equipment. This allows the operator or supervisor to:<\/p>\n<ul>\n<li>Monitor critical parameters in real time (pressure, airflow, filtration, temperature\u2026)<\/li>\n<li>Manage start-up, purge and alarm cycles<\/li>\n<li>Access user-specific operating modes<\/li>\n<li>Facilitate diagnostics and maintenance (error codes, event log)<\/li>\n<\/ul>\n<p>\ud83d\udca1 Benefit: simple, intuitive and secure control, with the possibility of integration into an existing industrial network (SCADA, MES\u2026).[\/vc_column_text][\/vc_column][vc_column css_animation=&#8221;fadeInRight&#8221; width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;3226&#8243; img_size=&#8221;full&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text el_class=&#8221;moyen-titre tres-fort txt-fort txt-blanc&#8221;]<\/p>\n<h3>Interlocking: operator and process safety<\/h3>\n<p>[\/vc_column_text][vc_column_text el_class=&#8221;txt-blanc&#8221;]We integrate mechanical or <strong>electronic interlocking systems<\/strong> to secure accesses and prevent inappropriate openings during a cycle. Typical features:<\/p>\n<ul>\n<li>Door locking when laminar flow is not operational<\/li>\n<li>Prevention of simultaneous opening of two airlocks (entry\/exit)<\/li>\n<li>Position sensing of small doors with status feedback to the HMI<\/li>\n<\/ul>\n<p>\ud83d\udca1 Benefit: reduced risk of cross-contamination and secured aseptic process without compromising ergonomics.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text el_class=&#8221;moyen-titre tres-fort txt-fort txt-blanc&#8221;]<\/p>\n<h3>Traceability and 21 CFR Part 11 compliance: guaranteed auditability<\/h3>\n<p>[\/vc_column_text][vc_column_text el_class=&#8221;txt-blanc&#8221;]Our solutions are compatible with electronic traceability requirements, for pharmaceutical environments subject to 21 CFR Part 11 (FDA) and Good Manufacturing Practices (GMP\/cGMP). You benefit from a full audit trail (time-stamped recording of user actions, parameter changes, openings, alarms\u2026), user profile management with authentication and hierarchical access rights, electronic signature to validate critical actions, and data export in compatible formats (CSV, PDF, XML\u2026).<br \/>\n\ud83d\udca1 Benefit: full documentary and regulatory compliance, easing quality inspections (ANSM, EMA, FDA\u2026).[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1768556665431{background-color: #384955 !important;}&#8221; el_class=&#8221;range-gris-fonce-bas arrondie-blanc&#8221;][vc_column][vc_empty_space height=&#8221;200px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;10&#8243;][vc_column_text el_class=&#8221;moyen-titre tres-fort&#8221;]<\/p>\n<p style=\"text-align: center;\">They trust us<\/p>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<p style=\"text-align: center;\"><style id=\"sp_wpcp_dynamic_css2365\">#wpcpro-wrapper-2365 #sp-wp-carousel-pro-id-2365.sp-wpcp-2365 .wpcp-all-captions .wpcp-image-caption a,#wpcpro-wrapper-2365 #sp-wp-carousel-pro-id-2365.sp-wpcp-2365 .wpcp-all-captions .wpcp-image-caption {color: #333;font-size: 15px;line-height: 23px;letter-spacing: 0px;text-transform: capitalize;margin-bottom: 0px;margin-top: 0px;text-align: center;}#wpcpro-wrapper-2365 #sp-wp-carousel-pro-id-2365.sp-wpcp-2365 .wpcp-all-captions .wpcp-image-description {color: #333;font-size: 14px;line-height: 21px;letter-spacing: 0px;margin-bottom: 0px;margin-top: 0px;text-transform: none;text-align: center;}.sp-wp-carousel-pro-id-2365 .fancybox-bg{background: #0b0b0b;opacity: 0.8;}.sp-wp-carousel-pro-id-2365.wpcp-fancybox-wrapper .fancybox-caption .wpcp_image_details,.sp-wp-carousel-pro-id-2365 .fancybox-caption .wpcp_image_details .wpcp_img_caption{color: #ffffff;}.sp-wp-carousel-pro-id-2365 .fancybox-caption .wpcp_image_details .wpcp_desc{color: 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{color: #fff;background: rgba(0, 0, 0, 0.8);}#wpcpro-wrapper-2365:not(.wpcpro-thumbnail-slider) .wpcp-swiper-wrapper{margin-bottom: 60px;}#wpcpro-wrapper-2365 .fashion-slider .wpcp-carousel-section{background-color: rgb(159, 160, 81);}.wpcpro-wrapper .wpcp-carousel-section.detail-on-right .wpcp-single-item,.wpcpro-wrapper .wpcp-carousel-section.detail-on-left .wpcp-single-item {flex-direction: column;}@media (min-width: 480px) {.wpcpro-row .wpcpro-col-sm-1 {flex: 0 0 100%;max-width: 100%;}.wpcpro-row .wpcpro-col-sm-2 {flex: 0 0 50%;max-width: 50%;}.wpcpro-row .wpcpro-col-sm-2-5 {flex: 0 0 75%;max-width: 75%;}.wpcpro-row .wpcpro-col-sm-3 {flex: 0 0 33.333%;max-width: 33.333%;}.wpcpro-row .wpcpro-col-sm-4 {flex: 0 0 25%;max-width: 25%;}.wpcpro-row .wpcpro-col-sm-5 {flex: 0 0 20%;max-width: 20%;}.wpcpro-row .wpcpro-col-sm-6 {flex: 0 0 16.66666666666667%;max-width: 16.66666666666667%;}.wpcpro-row .wpcpro-col-sm-7 {flex: 0 0 14.28571428%;max-width: 14.28571428%;}.wpcpro-row .wpcpro-col-sm-8 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75%;}.wpcpro-row .wpcpro-col-md-3 {flex: 0 0 33.333%;max-width: 33.333%;}.wpcpro-row .wpcpro-col-md-4 {flex: 0 0 25%;max-width: 25%;}.wpcpro-row .wpcpro-col-md-5 {flex: 0 0 20%;max-width: 20%;}.wpcpro-row .wpcpro-col-md-6 {flex: 0 0 16.66666666666667%;max-width: 16.66666666666667%;}.wpcpro-row .wpcpro-col-md-7 {flex: 0 0 14.28571428%;max-width: 14.28571428%;}.wpcpro-row .wpcpro-col-md-8 {flex: 0 0 12.5%;max-width: 12.5%;}}@media (min-width: 980px) {.wpcpro-row .wpcpro-col-lg-1 {flex: 0 0 100%;max-width: 100%;}.wpcpro-row .wpcpro-col-lg-2 {flex: 0 0 50%;max-width: 50%;}.wpcpro-row .wpcpro-col-lg-3 {flex: 0 0 33.222%;max-width: 33.222%;}.wpcpro-row .wpcpro-col-lg-4 {flex: 0 0 25%;max-width: 25%;}.wpcpro-row .wpcpro-col-lg-5 {flex: 0 0 20%;max-width: 20%;}.wpcpro-row .wpcpro-col-lg-6 {flex: 0 0 16.6667%;max-width: 16.6667%;}.wpcpro-row .wpcpro-col-lg-7 {flex: 0 0 14.28571428%;max-width: 14.28571428%;}.wpcpro-row .wpcpro-col-lg-8 {flex: 0 0 12.5%;max-width: 12.5%;}}@media (min-width: 1200px) {.wpcpro-row .wpcpro-col-xl-1 {flex: 0 0 100%;max-width: 100%;}.wpcpro-row .wpcpro-col-xl-2 {flex: 0 0 50%;max-width: 50%;}.wpcpro-row .wpcpro-col-xl-3 {flex: 0 0 33.22222222%;max-width: 33.22222222%;}.wpcpro-row .wpcpro-col-xl-4 {flex: 0 0 25%;max-width: 25%;}.wpcpro-row .wpcpro-col-xl-5 {flex: 0 0 20%;max-width: 20%;}.wpcpro-row .wpcpro-col-xl-6 {flex: 0 0 16.66667%;max-width: 16.66667%;}.wpcpro-row .wpcpro-col-xl-7 {flex: 0 0 14.28571428%;max-width: 14.28571428%;}.wpcpro-row .wpcpro-col-xl-8 {flex: 0 0 12.5%;max-width: 12.5%;}}<\/style><div id=\"wpcpro-wrapper-2365\" class=\"wpcp-carousel-wrapper wpcpro-wrapper wpcp-wrapper-2365\" data-slider-type=\"slide\" data-shaders-type=\"\" ><div id=\"wpcp-preloader-2365\" class=\"wpcp-carousel-preloader\"><img decoding=\"async\" src=\"https:\/\/www.avn-france.com\/wp-content\/plugins\/wp-carousel-pro\/src\/Frontend\/css\/spinner.svg\" class=\"skip-lazy\" alt=\"Preloader image\"\/><\/div><div id=\"sp-wp-carousel-pro-id-2365\" 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arrondie-blanc&#8221;][vc_column][vc_empty_space height=&#8221;200px&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; el_class=&#8221;txt-blanc&#8221; css=&#8221;.vc_custom_1765293247823{background-color: #384955 !important;}&#8221;][vc_column][vc_column_text el_class=&#8221;grand-titre tres-fort&#8221;] RABS: Restricted Access Barrier System or Isolator [\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; css=&#8221;.vc_custom_1708597892709{background-color: #384955 !important;}&#8221; el_class=&#8221;txt-blanc&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text] We support you in<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3179","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pharmaceutical Cleanroom, RABS Installation<\/title>\n<meta name=\"description\" content=\"VN France designs cleanroom installations for the pharmaceutical industry. 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